How aggregation occur in sickle cell anemia

How does aggregation occur in sickle-cell anemia? Place the steps in the correct order. Note that deoxyhemoglobin is generally in the T state; oxyhemoglobin is in the R state.
1.o2 decreases due to virgrous exercise or high altitude
2.R state Hb shift to Tstate Hb
3.Valine reacts with the pocket of a beta chain on another HBS
4.Another T-state HBS interact with growing aggreagation to form insoluble fiber

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