Solution-Important part of the g1-s transition checkpoint

Cell cycle checkpoints are an important feature of a dividing cell to reduce errors that can occur in various stages of the cell cycle. Loss of Rb, an important part of the G1-S transition checkpoint, can result in uncontrolled cell cycle progression and cancer. All of the following would mimic loss of Rb except:

  • Constitutively active G1-CDK
  • Constitutively active ERK
  • Constitutively active E2F
  • Constitutively active Myc
  • Constitutively active Ras GTPase activating protein

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