Describe the yeast alcohol dehydrogenase catalyzes

Yeast alcohol dehydrogenase catalyzes the conversion of acetaldehyde to ethanol, and important enzyme for all brewers of beer and bakers of bread. Load the structure of this enzyme (pdb =1AXG).

a. Draw a “roadkill” diagram showing all importantinteractions between the bound NAD and the enzyme (use chain A).Hint: start by drawing the structure of NAD (see page 327) and then”build” all the interactions onto that structure.

b. The “business” end of NAD is the nicotinamide ring,which does hydride transfer to the acetaldehyde substrate. How welldo you think the enzyme will work with an NAD analog that containsonly the nicotinamide ring? Why or why not?

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