Use recombinant dna methods to prepare a mutant

A drug company decided to use recombinant DNA methods to prepare a mutant

a1-antiproteinase (also sometimes referred to by its old name, a1-antitrypsin) that would be moreresistant to oxidation than the naturally occurring inhibitor, to administer intravenously to emphysemapatients. What single amino acid substitution would you recommend, and why?

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